Paraparesis, hypermanganesaemia, and polycythaemia: a novel presentation of cirrhosis.

@article{Gospe2000ParaparesisHA,
  title={Paraparesis, hypermanganesaemia, and polycythaemia: a novel presentation of cirrhosis.},
  author={Sidney M. Gospe and Ronald D. Caruso and Michael S. Clegg and Carl L. Keen and Neville Roy Pimstone and Jonathan M. Ducore and Sharmeen Gettner and Richard A Kreutzer},
  journal={Archives of disease in childhood},
  year={2000},
  volume={83 5},
  pages={439-42}
}
Progressive myelopathy is a rare complication of chronic hepatic disease which has never been reported in the paediatric age group. We describe the 11 year course of an adolescent male with hepatic myelopathy caused by cryptogenic micronodular cirrhosis. His condition has been associated with persistent polycythaemia and extraordinary increases of whole blood manganese, with magnetic resonance imaging evidence of manganese deposition within the basal ganglia and other regions of the brain. The… CONTINUE READING