Paraoxonases-1, -2 and -3: What are their functions?

@article{Furlong2016Paraoxonases1A,
  title={Paraoxonases-1, -2 and -3: What are their functions?},
  author={Clement E. Furlong and Judit Marsillach and Gail P. Jarvik and Lilian Gasparetto Costa},
  journal={Chemico-biological interactions},
  year={2016},
  volume={259 Pt B},
  pages={
          51-62
        }
}
Paraoxonase-1 (PON1), an esterase/lactonase primarily associated with plasma high-density lipoprotein (HDL), was the first member of this family of enzymes to be characterized. Its name was derived from its ability to hydrolyze paraoxon, the toxic metabolite of the insecticide parathion. Related enzymes PON2 and PON3 were named from their evolutionary relationship with PON1. Mice with each PON gene knocked out were generated at UCLA and have been key for elucidating their roles in… CONTINUE READING
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