Paraoxonase2 polymorphisms are associated with nephropathy in Type II diabetes

  title={Paraoxonase2 polymorphisms are associated with nephropathy in Type II diabetes},
  author={M E Pinizzotto and Edward Castillo and Muriel Fiaux and E. Temler and Rolf Christian Gaillard and Juan Ram{\'o}n Gonz{\'a}lez Ruiz},
Aims/hypothesis. Paraoxonase is a member of a multigene family of three genes. Paraoxonase2 gene polymorphisms have been associated with coronary heart disease in non-diabetic patients and with an increased fasting glycaemia in patients with Type II (non-insulin-dependent) diabetes mellitus. We tested the hypothesis of whether paraoxonase1 and paraoxonase2 polymorphisms were associated with diabetic nephropathy.¶Methods. Our case-control study of 299 Swiss patients with Type II diabetes… CONTINUE READING


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