Paraoxonase producing PON1 gene M/L55 polymorphism is related to autopsy-verified artery-wall atherosclerosis.

@article{Malin2001ParaoxonasePP,
  title={Paraoxonase producing PON1 gene M/L55 polymorphism is related to autopsy-verified artery-wall atherosclerosis.},
  author={Riikka Malin and Otso J{\"a}rvinen and Tero Sisto and T. A. Koivula and Terho Lehtim{\"a}ki},
  journal={Atherosclerosis},
  year={2001},
  volume={157 2},
  pages={301-7}
}
Paraoxonase (PON) is an antioxidative enzyme, which eliminates lipid peroxides. PON has two common polymorphisms (M/L55 and R/Q192) that influence PON concentration and activity. We studied whether the M/L55 or R/Q192 genotype relates with the severity of atherosclerosis of the abdominal aorta, and the mesenteric and common iliac arteries in 123 consecutive autopsy cases (90 males and 33 females, aged 18-93 years). The severity of atherosclerosis in the arteries was evaluated, and the… CONTINUE READING
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