Paraoxonase gene polymorphisms and plasma oxidized low-density lipoprotein level as possible risk factors for exudative age-related macular degeneration.

@article{Ikeda2001ParaoxonaseGP,
  title={Paraoxonase gene polymorphisms and plasma oxidized low-density lipoprotein level as possible risk factors for exudative age-related macular degeneration.},
  author={Tsunehiko Ikeda and Hiroshi Obayashi and Goji Hasegawa and Naoya Nakamura and Tadanobu Yoshikawa and Yutaka Imamura and Kan Koizumi and Sigenori Kinoshita},
  journal={American journal of ophthalmology},
  year={2001},
  volume={132 2},
  pages={
          191-5
        }
}
PURPOSE Paraoxonase (E.C.3.1.1.2) is a polymorphic protein shown to prevent low-density lipoprotein oxidation. Our purpose is to evaluate the hypothesis that paraoxonase gene polymorphisms and plasma oxidized low-density lipoprotein level play a role in the occurrence of exudative age-related macular degeneration. METHODS We analyzed paraoxonase genotypes (A/B, Gln-Arg192 and L/M, Leu-Met54) and plasma oxidized low-density lipoprotein levels in 72 unrelated Japanese patients with exudative… CONTINUE READING

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