Paraoxonase activity and genetic polymorphisms in greenhouse workers with long term pesticide exposure.

@article{Hernndez2003ParaoxonaseAA,
  title={Paraoxonase activity and genetic polymorphisms in greenhouse workers with long term pesticide exposure.},
  author={Antonio F. Hern{\'a}ndez and Bharti Mackness and Lourdes Rodrigo and Olga Lucia Lopez and A. Plana Pla and Francisco Gil and Paul N. Durrington and Gloria Pe{\~n}a and Tesif{\'o}n Parr{\'o}n and Jose L. Serrano and Michael Ian Mackness},
  journal={Human & experimental toxicology},
  year={2003},
  volume={22 11},
  pages={565-74}
}
Serum paraoxonase (PON1) is a high-density lipoprotein (HDL) associated protein, which plays a critical role in the pathogenesis of atherosclerosis, although it was primarily associated with the hydrolysis of organophosphorus compounds. PON1 was initially thought to be independent from physiological or pathological states, although recently some environmental factors have been reported to modulate its activity. In this study, we have investigated the promoter (PON1 -108C/T and -909 C/G) and… CONTINUE READING