Paraoxonase PON1 polymorphism leu-Met54 is associated with carotid atherosclerosis: results of the Austrian Stroke Prevention Study.

@article{Schmidt1998ParaoxonasePP,
  title={Paraoxonase PON1 polymorphism leu-Met54 is associated with carotid atherosclerosis: results of the Austrian Stroke Prevention Study.},
  author={Helena Schmidt and Reinhold Schmidt and Kurt Niederkorn and A Gradert and Martin R. Schumacher and Norbert Watzinger and H. P. Hartung and Gert M. Kostner},
  journal={Stroke},
  year={1998},
  volume={29 10},
  pages={2043-8}
}
BACKGROUND AND PURPOSE Genetic polymorphism at the paraoxonase locus is associated with serum concentration and activity of paraoxonase and with increased risk for coronary heart disease. Two frequent polymorphisms present at the paraoxonase gene are the methionine (M allele) leucine (L allele) interchange at position 54 and the arginine (B allele) glutamine (A allele) interchange at position 191. This is the first study to determine the effect of these polymorphisms on carotid atherosclerosis… CONTINUE READING

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Effect of the human serum paraoxonase 55 and 192 genetic polymorphisms on the protection by high density lipoprotein against low density lipoprotein oxidative modification

I Leviev, F Negro, RW James
FEBS Lett • 1998

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