Paraoxonase-3, a putative circulating antioxidant, is systemically up-regulated in late gestation in the fetal rat, sheep, and human.

@article{Belteki2010Paraoxonase3AP,
  title={Paraoxonase-3, a putative circulating antioxidant, is systemically up-regulated in late gestation in the fetal rat, sheep, and human.},
  author={Gusztav Belteki and Sarah L. Kempster and Alison J Forhead and Dino A Giussani and Abigail L Fowden and Anna E Curley and David Stephen Charnock-Jones and Gordon C S Smith},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2010},
  volume={95 8},
  pages={
          3798-805
        }
}
CONTEXT Surfactant is a successful therapeutic based on supplementing preterm infants with a substance that would normally have been up-regulated in late gestation. Although prematurity is associated with oxidative stress, no effective antioxidant therapy has yet been identified. OBJECTIVE Our objective was to identify endogenous antioxidants involved in fetal preparation for birth. DESIGN We performed transcript profiling of fetal rat lung and intestine at 16 d gestational age (dGA) and 20… CONTINUE READING

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