Paraoxonase 1 gene polymorphisms and enzyme activities in diabetes mellitus.

@article{Fleka2008Paraoxonase1G,
  title={Paraoxonase 1 gene polymorphisms and enzyme activities in diabetes mellitus.},
  author={Milan Fleka{\vc} and Jan V Skrha and Katerina Z{\'i}dkov{\'a} and Zdeňka Lacinov{\'a} and Jiřina Hilgertov{\'a}},
  journal={Physiological research},
  year={2008},
  volume={57 5},
  pages={
          717-26
        }
}
Paraoxonase 1 (PON1), an antioxidant enzyme closely associated with HDL (high-density lipoproteins), preserves LDL (low-density lipoproteins) against oxidation. Less protection may be therefore supposed by decreased PON1 activity. This study was undertaken to investigate the association of PON1 gene polymorphisms with diabetic angiopathy and to evaluate the relationship of these polymorphisms with PON1 activity. Total of 86 Type 1 (T1DM) and 246 Type 2 (T2DM) diabetic patients together with 110… CONTINUE READING
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