Paraoxonase 1 gene polymorphisms and enzyme activities in diabetes mellitus.

  title={Paraoxonase 1 gene polymorphisms and enzyme activities in diabetes mellitus.},
  author={Milan Fleka{\vc} and Jan V Skrha and Katerina Z{\'i}dkov{\'a} and Zdeňka Lacinov{\'a} and Jiřina Hilgertov{\'a}},
  journal={Physiological research},
  volume={57 5},
Paraoxonase 1 (PON1), an antioxidant enzyme closely associated with HDL (high-density lipoproteins), preserves LDL (low-density lipoproteins) against oxidation. Less protection may be therefore supposed by decreased PON1 activity. This study was undertaken to investigate the association of PON1 gene polymorphisms with diabetic angiopathy and to evaluate the relationship of these polymorphisms with PON1 activity. Total of 86 Type 1 (T1DM) and 246 Type 2 (T2DM) diabetic patients together with 110… CONTINUE READING
Highly Cited
This paper has 101 citations. REVIEW CITATIONS


Publications citing this paper.
Showing 1-10 of 38 extracted citations

Paraoxonase Activity and Gene Polymorphism in Rheumatoid Arthritis among Egyptians

Fathy. M. Elfasakhany, Saad A. Abou-Elnoeman, M Hussein, Hanadi A. Lamfoon, Mohamed M. Beyari
View 5 Excerpts
Highly Influenced

Implications of serum paraoxonase activity in obesity, diabetes mellitus, and dyslipidemia

Indian journal of endocrinology and metabolism • 2013
View 6 Excerpts
Highly Influenced

The genetics of vascular complications in diabetes mellitus.

Cardiology clinics • 2010
View 5 Excerpts
Highly Influenced

102 Citations

Citations per Year
Semantic Scholar estimates that this publication has 102 citations based on the available data.

See our FAQ for additional information.


Publications referenced by this paper.
Showing 1-10 of 27 references