Paraoxonase-1 concentrations in end-stage renal disease patients increase after hemodialysis: correlation with low molecular AGE adduct clearance.

@article{Gugliucci2007Paraoxonase1CI,
  title={Paraoxonase-1 concentrations in end-stage renal disease patients increase after hemodialysis: correlation with low molecular AGE adduct clearance.},
  author={Alejandro Gugliucci and Krista M. Mehlhaff and Eriko Kinugasa and Hiroaki Ogata and Ricardo Hermo and John R. Schulze and Satoshi Kensuke Kimura},
  journal={Clinica chimica acta; international journal of clinical chemistry},
  year={2007},
  volume={377 1-2},
  pages={213-20}
}
BACKGROUND Hemorrhagic stroke and ischemic heart disease continue to be key problems in patients with end stage renal failure. Reduced serum paraoxonase (PON-1) activity has been described in these patients, which could contribute to the accelerated development of atherosclerosis. We hypothesized that retention of uremic toxins and or "middle molecules" including advanced glycation (AGE) free adducts and peptides could play a mechanistic role in decreasing PON-1 activity. METHODS We enrolled… CONTINUE READING
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