Paraoxonase 1 and dietary hyperhomocysteinemia modulate the expression of mouse proteins involved in liver homeostasis.

@article{SuszyskaZajczyk2014Paraoxonase1A,
  title={Paraoxonase 1 and dietary hyperhomocysteinemia modulate the expression of mouse proteins involved in liver homeostasis.},
  author={Joanna Suszyńska-Zajczyk and Hieronim Jakubowski},
  journal={Acta biochimica Polonica},
  year={2014},
  volume={61 4},
  pages={
          815-23
        }
}
Homocysteine (Hcy), a product of methionine metabolism, is elevated by the consumption of a high-methionine diet that can cause fatty liver disease. Paraoxonase 1 (Pon1), a hydrolase expressed mainly in the liver and carried in the circulation on high-density lipoprotein, participates in Hcy metabolism. Low Pon1 activity is linked to fatty liver disease. We hypothesize that hyperhomocysteinemia and low Pon1 induce changes in gene expression that could impair liver homeostasis. To test this… CONTINUE READING

References

Publications referenced by this paper.
SHOWING 1-10 OF 61 REFERENCES

Altered gene expression in liver from a murine model of hyperhomocysteinemia.

  • The Journal of biological chemistry
  • 2003
VIEW 6 EXCERPTS
HIGHLY INFLUENTIAL

Inactivation of the paraoxonase 1 gene affects the expression of mouse brain proteins involved in neurodegeneration

J Suszyńska-Zajczyk, M Łuczak, Ł Marczak, H Jakubowski
  • J Alzheimers Dis
  • 2014
VIEW 8 EXCERPTS
HIGHLY INFLUENTIAL

Identification of N-homocysteinylated apolipoprotein AI in normal human serum.

  • Annals of clinical biochemistry
  • 2010
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL