Paraoxonase 1 192/55 gene polymorphisms in Alzheimer's disease.

  title={Paraoxonase 1 192/55 gene polymorphisms in Alzheimer's disease.},
  author={Thierry F Dantoine and Mireille Drouet and Jean Debord and Louis Merle and Michel Cogn{\'e} and Jean-Pierre Charmes},
  journal={Annals of the New York Academy of Sciences},
An esterase, paraoxonase 1 (PON1), protects against organophosphate neurotoxicity and decreases lipoprotein oxidation. Two polymorphisms of PON1 [192 (R or Q) and 55 (M or L)] exist and are associated with coronary artery disease. We have previously shown that serum PON1 activity (PON1a) is lower in vascular dementia (VaD) than in Alzheimer's disease (AD), suggesting that PON1a may distinguish VaD from AD. As PON1 polymorphism modifies PON1a, we determined 192 and 55 PON1 polymorphisms by… CONTINUE READING
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