Paraoxonase 1 (PON1) reduces macrophage inflammatory responses.

  title={Paraoxonase 1 (PON1) reduces macrophage inflammatory responses.},
  author={Saar Aharoni and Michael Y Aviram and Bianca Fuhrman},
  volume={228 2},
OBJECTIVES Paraoxonase 1 (PON1) was suggested to play an anti-inflammatory role. In the present study we questioned whether PON1 has a direct impact on macrophage inflammatory responses, and the possible functional implications of such effects. METHODS AND RESULTS Ex-vivo studies were performed with bone marrow-derived macrophages (BMDM) harvested from C57BL/6 and human-PON1 transgenic (PON1-Tg) mice, and for the in vitro studies the J774.A1 macrophage-like cell line was used. Pro… CONTINUE READING