Paraoxonase (PON1) phenotype is a better predictor of vascular disease than is PON1(192) or PON1(55) genotype.

@article{Jarvik2000ParaoxonaseP,
  title={Paraoxonase (PON1) phenotype is a better predictor of vascular disease than is PON1(192) or PON1(55) genotype.},
  author={Gail P. Jarvik and Laura S. Rozek and Victoria H. Brophy and Thomas S. Hatsukami and Rebecca J. Richter and Gerard D. Schellenberg and Clement E. Furlong},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2000},
  volume={20 11},
  pages={2441-7}
}
The paraoxonase (PON1) PON1-Q192R and PON1-L55M polymorphisms have been inconsistently associated with vascular disease. Plasma PON1 activity phenotypes vary markedly within genotypes and were, therefore, expected to add to the informativeness of genotype for predicting vascular disease. The case-control sample included 212 age- and race-matched men (mean age 66.4 years). The 106 carotid artery disease (CAAD) cases had >80% carotid stenosis, and the 106 controls had <15%. Two PON1 substrate… CONTINUE READING

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