Paraoxon has only a minimal effect on pralidoxime brain concentration in rats.

@article{Petroianu2007ParaoxonHO,
  title={Paraoxon has only a minimal effect on pralidoxime brain concentration in rats.},
  author={Georg A Petroianu and Dietrich E Lorke and Mohamed Yousif Hasan and Abdu Adem and R. R.-B. Sheen and Syed Muhammad Nurulain and Huba Kal{\'a}sz},
  journal={Journal of applied toxicology : JAT},
  year={2007},
  volume={27 4},
  pages={350-7}
}
Clinical experience with oximes, cholinesterase reactivators used in organophosphorus poisoning, has been disappointing. Their major anatomic site of therapeutic action and their ability to pass the blood-brain barrier (BBB) are controversial. Although their physico-chemical properties do not favour BBB penetration, access of oximes to the brain may be facilitated by organophosphates. The effect of the organophosphate paraoxon (POX) on pralidoxime (2-PAM) brain entry was therefore determined… CONTINUE READING

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