Paraoxon and Pyridostigmine Interfere with Neural Stem Cell Differentiation

@article{Berros2015ParaoxonAP,
  title={Paraoxon and Pyridostigmine Interfere with Neural Stem Cell Differentiation},
  author={Ver{\'o}nica O. Berr{\'i}os and Nawal M Boukli and J. Wilfrido Rodriguez and Priscilla D Negraes and Telma T Schwindt and Cleber A Trujillo and Sophia L. B. Oliveira and Luis A. Cubano and Pedro A. Ferchmin and Vesna A. Eterovi{\'c} and Henning Ulrich and Antonio Henrique Martins},
  journal={Neurochemical Research},
  year={2015},
  volume={40},
  pages={2091-2101}
}
Acetylcholinesterase (AChE) inhibition has been described as the main mechanism of organophosphate (OP)-evoked toxicity. OPs represent a human health threat, because chronic exposure to low doses can damage the developing brain, and acute exposure can produce long-lasting damage to adult brains, despite post-exposure medical countermeasures. Although the main mechanism of OP toxicity is AChE inhibition, several lines of evidence suggest that OPs also act by other mechanisms. We hypothesized… CONTINUE READING

References

Publications referenced by this paper.
Showing 1-10 of 27 references

safety aspects of nonacetylcholinesterase secondary targets

JE Casida, Quistad GB Organophosphate toxicology
Chem Res Toxicol 17(8):983–998 Table 1 continued Spots GI# Protein name MW (kDa) PI Peptides Protein scores Gel (spot location) Fold change POX compared to PG Fold change PY compared to PG 33 109486214 Phosphatidyiirtositol-3-phosphate/ phosphatidyiirtositol 245.02 6.35 24 64 POX -3.86 -1.08 • 2015
View 1 Excerpt

Total drug treatment and comorbidity in myasthenia gravis : a population-based cohort study

J. B. Andersena, J. F. Oweb, A. Engelandc, N. E. Gilhusa
2014
View 1 Excerpt

Acetylcholinesterase inhibitors: a patent review (2008 - present).

Expert opinion on therapeutic patents • 2012
View 1 Excerpt

2,3,7,8-Tetrachlorodibenzo-p-dioxin.

Report on carcinogens : carcinogen profiles • 2011
View 1 Excerpt

Similar Papers

Loading similar papers…