Paraoxon and Pyridostigmine Interfere with Neural Stem Cell Differentiation

  title={Paraoxon and Pyridostigmine Interfere with Neural Stem Cell Differentiation},
  author={Ver{\'o}nica O. Berr{\'i}os and Nawal M Boukli and J. Wilfrido Rodriguez and Priscilla D Negraes and Telma T Schwindt and Cleber A Trujillo and Sophia L. B. Oliveira and Luis A. Cubano and Pedro A. Ferchmin and Vesna A. Eterovi{\'c} and Henning Ulrich and Antonio Henrique Martins},
  journal={Neurochemical Research},
Acetylcholinesterase (AChE) inhibition has been described as the main mechanism of organophosphate (OP)-evoked toxicity. OPs represent a human health threat, because chronic exposure to low doses can damage the developing brain, and acute exposure can produce long-lasting damage to adult brains, despite post-exposure medical countermeasures. Although the main mechanism of OP toxicity is AChE inhibition, several lines of evidence suggest that OPs also act by other mechanisms. We hypothesized… CONTINUE READING


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