Paraneoplastic limbic encephalitis: neurological symptoms, immunological findings and tumour association in 50 patients.

  title={Paraneoplastic limbic encephalitis: neurological symptoms, immunological findings and tumour association in 50 patients.},
  author={S. Humayun Gultekin and Myrna R. Rosenfeld and Raymond Voltz and J G Eichen and Jerome B. Posner and Josep Dalmau},
  journal={Brain : a journal of neurology},
  volume={123 ( Pt 7)},
Paraneoplastic limbic encephalitis (PLE) is a rare disorder characterized by personality changes, irritability, depression, seizures, memory loss and sometimes dementia. The diagnosis is difficult because clinical markers are often lacking, and symptoms usually precede the diagnosis of cancer or mimic other complications. The frequency of antineuronal antibodies in patients with PLE has not been investigated. We examined the neurological symptoms and the causal tumours in 50 patients with PLE… 

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