Paraneoplastic gastro-intestinal anti-Hu syndrome in neuroblastoma.


The anti-Hu syndrome is a well-known paraneoplastic syndrome and may be rarely seen in patients with neuroblastoma. However, it is relatively unknown that anti-Hu antibodies can cause gastro-intestinal signs and symptoms. We report on a child with neuroblastoma who presented with gastro-intestinal disturbances as a result of the anti-Hu syndrome and summaries two similar case reports reported in literature. Neuroblastoma patients with gastro-intestinal disturbances, ranging from constipation to a paralytic ileus, might suffer from the gastro-intestinal anti-Hu syndrome. The causative antibodies can be determined to diagnose or exclude this syndrome, and successful treatment is possible.

DOI: 10.1002/pbc.21807

Cite this paper

@article{Drukker2009ParaneoplasticGA, title={Paraneoplastic gastro-intestinal anti-Hu syndrome in neuroblastoma.}, author={C A M Drukker and Hugo A. Heij and Liliane C. D. Wijnaendts and Jonathan I. M. L. Verbeke and Gertjan J. L. Kaspers}, journal={Pediatric blood & cancer}, year={2009}, volume={52 3}, pages={396-8} }