Paraneoplastic Brain Stem Encephalitis

@article{Blaes2013ParaneoplasticBS,
  title={Paraneoplastic Brain Stem Encephalitis},
  author={Franz Blaes},
  journal={Current Treatment Options in Neurology},
  year={2013},
  volume={15},
  pages={201-209}
}
  • F. Blaes
  • Published 3 February 2013
  • Medicine
  • Current Treatment Options in Neurology
Opinion statementParaneoplastic brain stem encephalitis can occur as an isolated clinical syndrome or, more often, may be part of a more widespread encephalitis. Different antineuronal autoantibodies, such as anti-Hu, anti-Ri, and anti-Ma2 can be associated with the syndrome, and the most frequent tumors are lung and testicular cancer. Anti-Hu-associated brain stem encephalitis does not normally respond to immunotherapy; the syndrome may stabilize under tumor treatment. Brain stem encephalitis… 
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References

SHOWING 1-10 OF 32 REFERENCES
Clinical analysis of anti-Ma2-associated encephalitis.
TLDR
Anti-Ma2 encephalitis (with or without anti-Ma1 antibodies) should be suspected in patients with limbic, diencephalic or brainstem dysfunction, MRI abnormalities in these regions, and inflammatory changes in the CSF.
Anti-Hu-associated brainstem encephalitis
TLDR
The study confirms the predominant medullary involvement but also shows that half of the patients present with clinical features that indicate an upper, mainly pontine, dysfunction before downward progression.
Anti-Hu-associated paraneoplastic encephalomyelitis: analysis of 200 patients.
TLDR
The predictors of mortality and PEM evolution found in the study may be important in the design of future therapeutic protocols, and emphasize the importance of early diagnosis and treatment of the underlying tumour.
Biphasic paraneoplastic brainstem encephalitis associated with anti-Ri antibody
TLDR
Immunosuppression with steroids and intravenous immune globulin combined with aggressive treatment of the tumor successfully led to the resolution of brainstem symptoms and MRI lesions.
Paraneoplastic brainstem encephalitis and anti-Ri antibodies
TLDR
It is emphasized that the brainstem is the major target of autoimmune dysfunction in patients with anti-Ri antibodies and as a result a wide spectrum of ocular motor disorders can be observed in this patient group.
[Paraneoplastic neurological syndromes].
The classic paraneoplastic neurological syndromes include Lambert-Eaton myasthenic syndrome, limbic encephalitis, sensory neuronopathy, intestinal pseudo-obstruction, subacute cerebellar
Anti-Ri-associated paraneoplastic cerebellar and brainstem degenerative syndrome.
We present the case of a female patient with a subacute paraneoplastic brainstem neurological syndrome associated with breast cancer and the development of anti-Ri antineuronal antibodies (ANNAs). It
Clinical outcome in adult onset idiopathic or paraneoplastic opsoclonus-myoclonus.
TLDR
It is concluded that idiopathic OMS occurs in younger patients, the clinical evolution is more benign and the effect of immunotherapy appears more effective than in paraneoplastic OMS.
Opsoclonus-myoclonus-ataxia syndrome in neuroblastoma: clinical outcome and antineuronal antibodies-a report from the Children's Cancer Group Study.
TLDR
Comparing the outcome of neuroblastoma patients with and without OMA, relating to prognostic factors, treatment, and the presence or absence of anti-neuronal antibodies found a significant correlation with lower stage disease compared to more advanced disease.
An update on opsoclonus
  • A. Wong
  • Biology, Medicine
    Current opinion in neurology
  • 2007
TLDR
There is increasing recognition that both humoral and cell mediated immune mechanisms are involved in the pathogenesis of opsoclonus, and further studies are needed to further elucidate its immunopathogenesis and pathophysiology in order to develop novel and efficacious therapy.
...
1
2
3
4
...