Paramyosin phosphorylation site disruption affects indirect flight muscle stiffness and power generation in Drosophila melanogaster.

@article{Liu2005ParamyosinPS,
  title={Paramyosin phosphorylation site disruption affects indirect flight muscle stiffness and power generation in Drosophila melanogaster.},
  author={Hongjun Liu and Mark S. Miller and Douglas M. Swank and William A. Kronert and David W. Maughan and Sanford I Bernstein},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2005},
  volume={102 30},
  pages={10522-7}
}
The phosphoprotein paramyosin is a major structural component of invertebrate muscle thick filaments. To investigate the importance of paramyosin phosphorylation, we produced transgenic Drosophila melanogaster in which one, three, or four phosphorylatable serine residues in the N-terminal nonhelical domain were replaced by alanines. Depending on the residues mutated, transgenic lines were either unaffected or severely flight impaired. Flight-impaired strains had decreases in the most acidic… CONTINUE READING