Paramutation: a process for acquiring trans-generational regulatory states.

@article{Erhard2011ParamutationAP,
  title={Paramutation: a process for acquiring trans-generational regulatory states.},
  author={Karl F. Erhard and Jay Brian Hollick},
  journal={Current opinion in plant biology},
  year={2011},
  volume={14 2},
  pages={210-6}
}
Basic tenets of Mendelian inheritance are violated by paramutations in which trans-homolog interactions lead to heritable changes in gene regulation and phenotype. First described in plants, similar behaviors have now been noted in diverse eukaryotes. Genetic and molecular studies of paramutations occurring in maize indicate that components of a small interfering RNA (siRNA) biogenesis pathway are required for the maintenance of meiotically heritable regulatory states. Although these findings… CONTINUE READING

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