Parametrization of electrophilicity for the prediction of the toxicity of aromatic compounds.

@article{Cronin2001ParametrizationOE,
  title={Parametrization of electrophilicity for the prediction of the toxicity of aromatic compounds.},
  author={Mark T. D. Cronin and Nia Manga and Julie R Seward and Glendon D Sinks and T. Wayne Schultz},
  journal={Chemical research in toxicology},
  year={2001},
  volume={14 11},
  pages={1498-505}
}
The aim of this study was to determine which descriptor best parametrized the electrophilicity of aromatic compounds with regard to their acute toxicity. To achieve this, toxicity data for 203 substituted aromatic compounds containing a nitro- or cyano group were evaluated in the 40-h Tetrahymena pyriformis population growth impairment assay. Quantitative structure-activity relationships (QSARs) were developed relating toxic potency [log(IGC(50)(-1))] with hydrophobicity quantified by the 1… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 16 extracted citations

Similar Papers

Loading similar papers…