Parametric modeling and optimal experimental designs for estimating isobolograms for drug interactions in toxicology.

@article{HollandLetz2018ParametricMA,
  title={Parametric modeling and optimal experimental designs for estimating isobolograms for drug interactions in toxicology.},
  author={Tim Holland-Letz and Nikolas Gunkel and Eberhard Amtmann and Annette Kopp-Schneider},
  journal={Journal of biopharmaceutical statistics},
  year={2018},
  volume={28 4},
  pages={
          763-777
        }
}
In toxicology and related areas, interaction effects between two substances are commonly expressed through a combination index [Formula: see text] evaluated separately at different effect levels and mixture ratios. Often, these indices are combined into a graphical representation, the isobologram. Instead of estimating the combination indices at the… CONTINUE READING