Parametric Complexity of Sequence Assembly: Theory and Applications to Next Generation Sequencing

@article{Nagarajan2009ParametricCO,
  title={Parametric Complexity of Sequence Assembly: Theory and Applications to Next Generation Sequencing},
  author={Niranjan Nagarajan and Mihai Pop},
  journal={Journal of computational biology : a journal of computational molecular cell biology},
  year={2009},
  volume={16 7},
  pages={897-908}
}
In recent years, a flurry of new DNA sequencing technologies have altered the landscape of genomics, providing a vast amount of sequence information at a fraction of the costs that were previously feasible. The task of assembling these sequences into a genome has, however, still remained an algorithmic challenge that is in practice answered by heuristic solutions. In order to design better assembly algorithms and exploit the characteristics of sequence data from new technologies, we need an… CONTINUE READING
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