Parameters of glucose metabolism and the aging brain: a magnetization transfer imaging study of brain macro- and micro-structure in older adults without diabetes

@inproceedings{Akintola2015ParametersOG,
  title={Parameters of glucose metabolism and the aging brain: a magnetization transfer imaging study of brain macro- and micro-structure in older adults without diabetes},
  author={Abimbola A. Akintola and Annette van den Berg and Irmhild Altmann-Schneider and Steffy W. M. Jansen and Mark A. van Buchem and Pieternella E Slagboom and Rudi G J Westendorp and Diana van Heemst and J van der Grond},
  booktitle={AGE},
  year={2015}
}
Given the concurrent, escalating epidemic of diabetes mellitus and neurodegenerative diseases, two age-related disorders, we aimed to understand the relation between parameters of glucose metabolism and indices of pathology in the aging brain. From the Leiden Longevity Study, 132 participants (mean age 66 years) underwent a 2-h oral glucose tolerance test to assess glucose tolerance (fasted and area under the curve (AUC) glucose), insulin sensitivity (fasted and AUC insulin and homeostatic… CONTINUE READING
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