Parameters of CpG oligodeoxynucleotide-induced protection against intravaginal HSV-2 challenge.

@article{Sajic2003ParametersOC,
  title={Parameters of CpG oligodeoxynucleotide-induced protection against intravaginal HSV-2 challenge.},
  author={Dusan Sajic and Ali A Ashkar and Amy J Patrick and Michael J McCluskie and Heather L. Davis and Kenneth L Levine and Richard Holl and Kenneth Lee Rosenthal},
  journal={Journal of medical virology},
  year={2003},
  volume={71 4},
  pages={561-8}
}
Synthetic oligodeoxynucleotides (ODN) containing unmethylated CpG dinucleotides within the context of certain flanking bases (CpG motifs) have been shown to induce potent innate and adaptive immune responses. Vaginal delivery of CpG ODN alone protects mice from vaginal herpes simplex virus type-2 (HSV-2) challenge. Here, we investigated the importance of timing of delivery, formulation, route and dose of vaginally administered CpG ODN in the prevention or treatment of intravaginal (IVAG) HSV-2… CONTINUE READING

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