Parameters for reliable results in genetic association studies in common disease

@article{Dahlman2002ParametersFR,
  title={Parameters for reliable results in genetic association studies in common disease},
  author={Ingrid Dahlman and Iain A. Eaves and Roman Kosoy and Virginia Morrison and Joanne M. Heward and Stephen C. L. Gough and Amit Allahabadia and Jayne A. Franklyn and Jaakko Tuomilehto and Eva Tuomilehto-Wolf and Francesco Cucca and Cristian Guja and Constantin Ionescu-Tirgoviste and Helen C. Stevens and Philippa Carr and Sarah Nutland and Patricia McKinney and Julian P. H. Shield and William G. J. Wang and Heather J. Cordell and Neil E. Walker and John A. Todd and Patrick Concannon},
  journal={Nature Genetics},
  year={2002},
  volume={30},
  pages={149-150}
}
It is increasingly apparent that the identification of true genetic associations in common multifactorial disease will require studies comprising thousands rather than the hundreds of individuals employed to date. Using 2,873 families, we were unable to confirm a recently published association of the interleukin 12B gene in 422 type I diabetic families. These results emphasize the need for large datasets, small P values and independent replication if results are to be reliable. 

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