Parameters for establishing humanized mouse models to study human immunity: analysis of human hematopoietic stem cell engraftment in three immunodeficient strains of mice bearing the IL2rgamma(null) mutation.

@article{Brehm2010ParametersFE,
  title={Parameters for establishing humanized mouse models to study human immunity: analysis of human hematopoietic stem cell engraftment in three immunodeficient strains of mice bearing the IL2rgamma(null) mutation.},
  author={Michael A Brehm and Amy Cuthbert and Chaoxing Yang and David M Miller and Philip Diiorio and Joseph C. Laning and Lisa M. Burzenski and Bruce Gott and Oded Foreman and Anoop Kavirayani and Mary M Herlihy and Aldo A. Rossini and Leonard D Shultz and Dale L. Greiner},
  journal={Clinical immunology},
  year={2010},
  volume={135 1},
  pages={
          84-98
        }
}
"Humanized" mouse models created by engraftment of immunodeficient mice with human hematolymphoid cells or tissues are an emerging technology with broad appeal across multiple biomedical disciplines. However, investigators wishing to utilize humanized mice with engrafted functional human immune systems are faced with a myriad of variables to consider. In this study, we analyze HSC engraftment methodologies using three immunodeficient mouse strains harboring the IL2rgamma(null) mutation; NOD… CONTINUE READING

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