Parameters affecting tumor-specific delivery of anti-CD5 antibody-ricin A chain immunotoxins in vivo.

@article{RostaingCapaillon1990ParametersAT,
  title={Parameters affecting tumor-specific delivery of anti-CD5 antibody-ricin A chain immunotoxins in vivo.},
  author={Odile Rostaing-Capaillon and Pierre Casellas},
  journal={Cancer research},
  year={1990},
  volume={50 10},
  pages={2909-16}
}
The tumor localization of various anti-CD5 immunotoxins (ITs) was studied in vivo in BALB/c nude mice bearing human ascitic Ichikawa tumor cells. Plasma and ascitic clearance of IT as well as the number of intact IT molecules taken up per tumor cell was measured with a highly sensitive immunoenzymometric assay. This assay allowed the quantification of as few as 400 molecules per cell, either bound to cell surface antigens or internalized. Tumor cell localization of an i.v.-administered IT… CONTINUE READING