Parameter identifiability and estimation of HIV/AIDS dynamic models.

  title={Parameter identifiability and estimation of HIV/AIDS dynamic models.},
  author={Hulin Wu and Haihong Zhu and Hongyu Miao and Alan S. Perelson},
  journal={Bulletin of mathematical biology},
  volume={70 3},
We use a technique from engineering (Xia and Moog, in IEEE Trans. Autom. Contr. 48(2):330-336, 2003; Jeffrey and Xia, in Tan, W.Y., Wu, H. (Eds.), Deterministic and Stochastic Models of AIDS Epidemics and HIV Infections with Intervention, 2005) to investigate the algebraic identifiability of a popular three-dimensional HIV/AIDS dynamic model containing six unknown parameters. We find that not all six parameters in the model can be identified if only the viral load is measured, instead only four… CONTINUE READING
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