Parameter estimation methods for gene circuit modeling from time-series mRNA data: a comparative study

Abstract

Parameter estimation is a challenging computational problem in the reverse engineering of biological systems. Because advances in biotechnology have facilitated wide availability of time-series gene expression data, systematic parameter estimation of gene circuit models from such time-series mRNA data has become an important method for quantitatively… (More)
DOI: 10.1093/bib/bbv015

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