Paramagnetic metal scavenging by melanin: MR imaging.

  title={Paramagnetic metal scavenging by melanin: MR imaging.},
  author={W Steven Enochs and P Petherick and Anna A Bogdanova and Ulrich Mohr and Ralph Weissleder},
  volume={204 2},
PURPOSE To quantitate the binding of metals to synthetic melanin in vitro, which is believed to be the reason why melanotic melanomas are hyperintense on T1-weighted magnetic resonance (MR) images, and to test whether such binding by natural melanin can be detected in cultured melanoma cells in vivo with MR imaging. MATERIALS AND METHODS Seven synthetic metallomelanins were prepared and their metal contents and relaxivities determined. Melanotic PC1A and amelanotic B16 melanoma cells were… CONTINUE READING

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