Parallels between embryo and cancer cell metabolism.

  title={Parallels between embryo and cancer cell metabolism.},
  author={Danielle G. Smith and Roger G S Sturmey},
  journal={Biochemical Society transactions},
  volume={41 2},
A key characteristic of cancer cells is the ability to switch from a predominantly oxidative metabolism to glycolysis and the production of lactate even when oxygen is plentiful. This metabolic switch, known as the Warburg effect, was first described in the 1920s, and has fascinated and puzzled researchers ever since. However, a dramatic increase in glycolysis in the presence of oxygen is one of the hallmarks of the development of the early mammalian embryo; a metabolic switch with many… CONTINUE READING
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Metabolism of the preimplantation embryo: 40 years on

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