Parallel synthesis of a series of non-functional ATP/NAD analogs with activity against trypanosomatid parasites

@article{Link2009ParallelSO,
  title={Parallel synthesis of a series of non-functional ATP/NAD analogs with activity against trypanosomatid parasites},
  author={Andreas Link and Philipp Heidler and M Kaiser and Reto Brun},
  journal={Molecular Diversity},
  year={2009},
  volume={14},
  pages={215-224}
}
Non-functional analogs of the cofactors ATP and NAD are putative inhibitors of ATP- or NAD-dependant enzymes. Since pathogenic protozoa rely heavily on the salvage of purine nucleosides from the bloodstream of their host, such compounds are of interest as antiplasmodial and antitrypanosomal agents with a multitude of molecular targets. By replacing the… CONTINUE READING