Parallel synthesis of 5-cyano-6-aryl-2-thiouracil derivatives as inhibitors for hepatitis C viral NS5B RNA-dependent RNA polymerase.

@article{Ding2006ParallelSO,
  title={Parallel synthesis of 5-cyano-6-aryl-2-thiouracil derivatives as inhibitors for hepatitis C viral NS5B RNA-dependent RNA polymerase.},
  author={Yili Ding and J. -L. Girardet and Kenneth L Smith and Gary Larson and Brett J. Prigaro and Jim Zhen Wu and Nanhua Yao},
  journal={Bioorganic chemistry},
  year={2006},
  volume={34 1},
  pages={26-38}
}
From random screening of our compound libraries, we identified a hit compound with an IC50 of 27 microM against hepatitis C viral NS5B RNA-dependent RNA polymerase. By using a parallel synthetic strategy, a series of its derivatives were synthesized. From their anti-HCV activity screening, compounds with single digital 3.8 micromolar activity were obtained. 

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