Parallel synthesis and biological evaluation of 837 analogues of procaspase-activating compound 1 (PAC-1).

Abstract

Procaspase-Activating Compound 1 (PAC-1) is an ortho-hydroxy N-acyl hydrazone that enhances the enzymatic activity of procaspase-3 in vitro and induces apoptosis in cancer cells. An analogue of PAC-1, called S-PAC-1, was evaluated in a veterinary clinical trial in pet dogs with lymphoma and found to have considerable potential as an anticancer agent. With… (More)
DOI: 10.1021/co2001372

Topics

5 Figures and Tables

Cite this paper

@article{Hsu2012ParallelSA, title={Parallel synthesis and biological evaluation of 837 analogues of procaspase-activating compound 1 (PAC-1).}, author={Danny C. Hsu and Howard S. Roth and Diana C. West and Rachel C. Botham and Chris J. Novotny and Steven C Schmid and Paul J. Hergenrother}, journal={ACS combinatorial science}, year={2012}, volume={14 1}, pages={44-50} }