Parallel substrate feeding and pH-control in shaking-flasks.

@article{WeusterBotz2001ParallelSF,
  title={Parallel substrate feeding and pH-control in shaking-flasks.},
  author={Dirk Weuster-Botz and Jutta Altenbach-Rehm and Manfred Arnold},
  journal={Biochemical engineering journal},
  year={2001},
  volume={7 2},
  pages={
          163-170
        }
}
An intermittent feeding system for shaking-flasks was developed to close the gap between batch operated shaking-flasks and fed-batch operated as well as pH-controlled stirred tank reactors. A precise syringe pump was connected via a substrate distribution system to individual 2/2-way miniature valves, one for each of up to 16 shaking-flask. The shaking-flasks were equipped with pH-probes. A process computer controls the intermittent feeding of substrates by tracking predefined individual… CONTINUE READING
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Critical analysis of engineering aspects of shaken flask bioreactors.

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