Parallel progression of primary tumours and metastases

  title={Parallel progression of primary tumours and metastases},
  author={Christoph A Klein},
  journal={Nature Reviews Cancer},
Systemic cancer progression is accounted for in two basic models. The prevailing archetype places the engine of cancer progression within the primary tumour before metastatic dissemination of fully malignant cells. The second posits parallel, independent progression of metastases arising from early disseminated tumour cells. This Perspective draws together data from disease courses, tumour growth rates, autopsy studies, clinical trials and molecular genetic analyses of primary and disseminated… CONTINUE READING
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Biological relevance of disseminated tumor cells in cancer patients

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