Parallel overlap assembly for the construction of computational DNA libraries.

  title={Parallel overlap assembly for the construction of computational DNA libraries.},
  author={Peter D. Kaplan and Q. Ouyang and David S. Thaler and Albert Libchaber},
  journal={Journal of theoretical biology},
  volume={188 3},
Algorithms for computing with DNA currently require the construction of pools of molecules in which each distinct molecule represents a different starting point for the calculation. We have begun building such pools using the technique of parallel overlap assembly that is already used for the generation of diversity in biologically useful combinatorial search techniques such as gene shuffling. Unlike these applications, a pool in a molecular computer must be complete, containing all possible… CONTINUE READING

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