Parallel karyotypic evolution and tumor progression in uterine leiomyoma.

  title={Parallel karyotypic evolution and tumor progression in uterine leiomyoma.},
  author={Nikos Pandis and Sverre Heim and Georgia Bardi and U. M. Flod{\'e}rus and Helena Will{\'e}n and Nils Mandahl and Felix Mitelman},
  journal={Genes, chromosomes & cancer},
  volume={2 4},
Cytogenetic evidence of clonal evolution was detected in five uterine leiomyomas. In two tumors, two clones were found, the third tumor had four, the fourth had nine, and the fifth had 12 clones. The first tumor had trisomy 12 as the primary anomaly and a sideline that also contained a del(7)(q21q31). Both clones of the second tumor had three structural changes in common but differed by the presence in the more advanced clone of an inv(7)(q31q34). Two cytogenetically unrelated pairs of clones… CONTINUE READING