Parallel instabilities of long-term potentiation, place cells, and learning caused by decreased protein kinase A activity.

@article{Rotenberg2000ParallelIO,
  title={Parallel instabilities of long-term potentiation, place cells, and learning caused by decreased protein kinase A activity.},
  author={Alexander Rotenberg and Ted Abel and R. David Hawkins and Eric R Kandel and Robert U. Muller},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2000},
  volume={20 21},
  pages={8096-102}
}
To further elucidate the links among synaptic plasticity, hippocampal place cells, and spatial memory, place cells were recorded from wild-type mice and transgenic "R(AB)" mice with reduced forebrain protein kinase A (PKA) activity after introduction into a novel environment. Place cells in both strains were similar during the first exposure and were equally stable for recording sessions separated by 1 hr. Place cell stability in wild-type mice was unchanged for sessions separated by 24 hr but… CONTINUE READING

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