Parallel improvement of cognitive functions and P300 latency following donepezil treatment in patients with Alzheimer's disease: a case-control study.

@article{Chang2014ParallelIO,
  title={Parallel improvement of cognitive functions and P300 latency following donepezil treatment in patients with Alzheimer's disease: a case-control study.},
  author={Yu-San Chang and Hsiang-Lan Chen and Chung-Yao Hsu and Shu-Hui Tang and Ching-Kuan Liu},
  journal={Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society},
  year={2014},
  volume={31 1},
  pages={81-5}
}
PURPOSE To evaluate the effect of donepezil, one of the cholinesterase inhibitors, on P300 measurements in patients with Alzheimer's disease (AD) and investigate the relationship between the subfactors of cognitive performance and P300 components. METHODS One hundred outpatients with AD were evaluated for cognitive function (cognitive ability screening instrument) and event-related potentials before and after 22 to 23 weeks of treatment with donepezil (5 mg/day). Twenty age-matched normal… CONTINUE READING