Parallel high-throughput RNA interference screens identify PINK1 as a potential therapeutic target for the treatment of DNA mismatch repair-deficient cancers.

@article{Martin2011ParallelHR,
  title={Parallel high-throughput RNA interference screens identify PINK1 as a potential therapeutic target for the treatment of DNA mismatch repair-deficient cancers.},
  author={Sarah Anne Martin and Madeleine Hewish and David Sims and Christopher J Lord and Alan Ashworth},
  journal={Cancer research},
  year={2011},
  volume={71 5},
  pages={1836-48}
}
Synthetic lethal approaches to cancer treatment have the potential to deliver relatively large therapeutic windows and therefore significant patient benefit. To identify potential therapeutic approaches for cancers deficient in DNA mismatch repair (MMR), we have carried out parallel high-throughput RNA interference screens using tumor cell models of MSH2- and MLH1-related MMR deficiency. We show that silencing of the PTEN-induced putative kinase 1 (PINK1), is synthetically lethal with MMR… CONTINUE READING

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References

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GammaH2AX and cancer

WM Bonner, CE Redon, +3 authors S Solier
Nat Rev Cancer 2008;8:957– • 2008

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