Parallel genetic and phenotypic evolution of DNA superhelicity in experimental populations of Escherichia coli.

@article{Crozat2010ParallelGA,
  title={Parallel genetic and phenotypic evolution of DNA superhelicity in experimental populations of Escherichia coli.},
  author={Estelle Crozat and Cynthia L. Winkworth and Jo{\"e}l Gaff{\'e} and Peter F. Hallin and Margaret A. Riley and Richard E. Lenski and Dominique Schneider},
  journal={Molecular biology and evolution},
  year={2010},
  volume={27 9},
  pages={2113-28}
}
DNA supercoiling is the master function that interconnects chromosome structure and global gene transcription. This function has recently been shown to be under strong selection in Escherichia coli. During the evolution of 12 initially identical populations propagated in a defined environment for 20,000 generations, parallel increases in DNA supercoiling were observed in ten populations. The genetic changes associated with the increased supercoiling were examined in one population, and… CONTINUE READING
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