Parallel functional activity profiling reveals valvulopathogens are potent 5-hydroxytryptamine(2B) receptor agonists: implications for drug safety assessment.

@article{Huang2009ParallelFA,
  title={Parallel functional activity profiling reveals valvulopathogens are potent 5-hydroxytryptamine(2B) receptor agonists: implications for drug safety assessment.},
  author={Xi-Ping Huang and Vincent Setola and Prem Narayan Yadav and John A. Allen and Sarah C. Rogan and Bonnie J. Hanson and Chetana Revankar and Matt Robers and Chris Doucette and Bryan L. Roth},
  journal={Molecular pharmacology},
  year={2009},
  volume={76 4},
  pages={710-22}
}
Drug-induced valvular heart disease (VHD) is a serious side effect of a few medications, including some that are on the market. Pharmacological studies of VHD-associated medications (e.g., fenfluramine, pergolide, methysergide, and cabergoline) have revealed that they and/or their metabolites are potent 5-hydroxytryptamine(2B) (5-HT(2B)) receptor agonists. We have shown that activation of 5-HT(2B) receptors on human heart valve interstitial cells in vitro induces a proliferative response… CONTINUE READING
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