Parallel declines in Fos activation of the medial anteroventral periventricular nucleus and LHRH neurons in middle-aged rats.

@article{Le2001ParallelDI,
  title={Parallel declines in Fos activation of the medial anteroventral periventricular nucleus and LHRH neurons in middle-aged rats.},
  author={Wei Wei Le and Phyllis M. Wise and Anne Z Murphy and Lique M Coolen and Gloria E. Hoffman},
  journal={Endocrinology},
  year={2001},
  volume={142 11},
  pages={
          4976-82
        }
}
The middle-age decline in reproductive function is manifested by reduced LHRH release, resulting in a decreased magnitude and delay of onset of the LH surge. Earlier studies suggested that the reductions in LHRH neural activation in middle-aged rats resulted from deficits in the afferent drive to the LHRH neurons. One critical afferent to the LHRH neurons lies in the anteroventral periventricular preoptic area (AVPv) nucleus. The neurons of the medial AVPv are synchronously activated to express… CONTINUE READING

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