Parallel contributions of cerebellar, striatal and M1 mechanisms to motor sequence learning

  title={Parallel contributions of cerebellar, striatal and M1 mechanisms to motor sequence learning},
  author={Virginia B. Penhune and Christopher John Steele},
  journal={Behavioural Brain Research},

Figures from this paper

Current issues related to motor sequence learning in humans

Multiple Motor Learning Processes in Humans: Defining Their Neurophysiological Bases

  • D. SpampinatoP. Celnik
  • Biology, Psychology
    The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry
  • 2020
How changes in human physiological markers, assessed with noninvasive brain stimulation techniques from distinct brain regions, can be utilized to provide insights toward the distinct learning processes underlying motor learning is discussed.

Consolidating behavioral and neurophysiologic findings to explain the influence of contextual interference during motor sequence learning

This account focuses on important contributions from two neural regions—the dorsal premotor area and the SMA complex—that are recruited earlier and more extensively during the planning of a motor sequence in a high CI context and proposes that activation of these regions is critical to early adaptation of sequence structure amenable to long-term storage.

Motor Performance But Neither Motor Learning Nor Motor Consolidation Are Impaired in Chronic Cerebellar Stroke Patients

It is suggested that residual functional impairments caused by cerebellar stroke may be mitigated even months later by additional skill training, and the role of the cerebellum in online and offline motor sequence learning seems to be either negligible or amenable to compensatory mechanisms.

Spatiotemporal dissociation of fMRI activity in the caudate nucleus underlies human de novo motor skill learning

A double dissociation of fMRI activity in the anterior and posterior caudate nucleus was discovered, which was associated with performance in the early and late learning stages, and results suggest parallel cortico-caudate networks operating in different stages of human de novo motor skill learning.

The Human Motor System Supports Sequence-Specific Representations over Multiple Training-Dependent Timescales.

It is hypothesized that within each motor region, the strength of any sequence representation is a non-linear function that can be characterized by 3 timescales, underscoring the capacity of the motor system to flexibly represent a sequence based on the amount of prior experience.



A computational neuroanatomy for motor control

It is argued that the lesion approach and theoretical motor control can mutually inform each other and one may identify distinct motor control processes from computational models and map them onto specific deficits in patients.

Experience-dependent changes in cerebellar contributions to motor sequence learning

Results indicate that intrinsic modulation within the cerebellum, in concert with activation of motor-related cortical regions, serves to set up a procedurally acquired sequence of movements that is then maintained elsewhere in the brain.

Specific Increases within Global Decreases: A Functional Magnetic Resonance Imaging Investigation of Five Days of Motor Sequence Learning

Functional magnetic resonance imaging was used to identify the specific contributions of the cerebellum and primary motor cortex during early learning, consolidation, and retention of a motor sequence task, suggesting that these networks optimize different components of learning.

Role of monkey cerebellar nuclei in skill for sequential movement.

The results suggest that, among the cerebellar nuclei, the dentate nucleus, especially its dorsal and central regions, is related to the storage and/or retrieval of long-term memory for motor skill.

Human cerebellar activity reflecting an acquired internal model of a new tool

A coherent computational theory is proposed in which the phylogenetically newer part of the cerebellum similarly acquires internal models of objects in the external world through motor learning.

Contributions of the basal ganglia and functionally related brain structures to motor learning

Distinct basal ganglia territories are engaged in early and advanced motor sequence learning.

  • S. LehéricyH. Benali J. Doyon
  • Psychology, Biology
    Proceedings of the National Academy of Sciences of the United States of America
  • 2005
The results suggest the possibility that motor representations shift from the associative to the sensorimotor territories of the striato-pallidal complex during the explicit learning of motor sequences, suggesting that motor skills are stored in the sensorsimotor territory of the basal ganglia that supports a speedy performance.

Functional Stages in the Formation of Human Long-Term Motor Memory

It is demonstrated that two motor maps may be learned and retained, but only if the training sessions in the tasks are separated by an interval of ∼5 hr, and raised the possibility that there are distinct neuronal mechanisms for representation of the two functional stages of motor memory.