Parallel contributions of cerebellar, striatal and M1 mechanisms to motor sequence learning

@article{Penhune2012ParallelCO,
  title={Parallel contributions of cerebellar, striatal and M1 mechanisms to motor sequence learning},
  author={Virginia B. Penhune and Christopher John Steele},
  journal={Behavioural Brain Research},
  year={2012},
  volume={226},
  pages={579-591}
}

Figures from this paper

Current issues related to motor sequence learning in humans

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References

SHOWING 1-10 OF 147 REFERENCES

A computational neuroanatomy for motor control

TLDR
It is argued that the lesion approach and theoretical motor control can mutually inform each other and one may identify distinct motor control processes from computational models and map them onto specific deficits in patients.

Experience-dependent changes in cerebellar contributions to motor sequence learning

TLDR
Results indicate that intrinsic modulation within the cerebellum, in concert with activation of motor-related cortical regions, serves to set up a procedurally acquired sequence of movements that is then maintained elsewhere in the brain.

Specific Increases within Global Decreases: A Functional Magnetic Resonance Imaging Investigation of Five Days of Motor Sequence Learning

TLDR
Functional magnetic resonance imaging was used to identify the specific contributions of the cerebellum and primary motor cortex during early learning, consolidation, and retention of a motor sequence task, suggesting that these networks optimize different components of learning.

Role of monkey cerebellar nuclei in skill for sequential movement.

TLDR
The results suggest that, among the cerebellar nuclei, the dentate nucleus, especially its dorsal and central regions, is related to the storage and/or retrieval of long-term memory for motor skill.

Human cerebellar activity reflecting an acquired internal model of a new tool

TLDR
A coherent computational theory is proposed in which the phylogenetically newer part of the cerebellum similarly acquires internal models of objects in the external world through motor learning.

Contributions of the basal ganglia and functionally related brain structures to motor learning

Distinct basal ganglia territories are engaged in early and advanced motor sequence learning.

  • S. LehéricyH. Benali J. Doyon
  • Psychology, Biology
    Proceedings of the National Academy of Sciences of the United States of America
  • 2005
TLDR
The results suggest the possibility that motor representations shift from the associative to the sensorimotor territories of the striato-pallidal complex during the explicit learning of motor sequences, suggesting that motor skills are stored in the sensorsimotor territory of the basal ganglia that supports a speedy performance.

Functional Stages in the Formation of Human Long-Term Motor Memory

TLDR
It is demonstrated that two motor maps may be learned and retained, but only if the training sessions in the tasks are separated by an interval of ∼5 hr, and raised the possibility that there are distinct neuronal mechanisms for representation of the two functional stages of motor memory.
...