Parallel activation of de novo lipogenesis and stearoyl-CoA desaturase activity after 3 d of high-carbohydrate feeding.

@article{Chong2008ParallelAO,
  title={Parallel activation of de novo lipogenesis and stearoyl-CoA desaturase activity after 3 d of high-carbohydrate feeding.},
  author={Mary F-F Chong and Leanne Hodson and Alex S T Bickerton and Rachel Roberts and Matt Neville and Fredrik Karpe and Keith N. Frayn and Barbara A. Fielding},
  journal={The American journal of clinical nutrition},
  year={2008},
  volume={87 4},
  pages={817-23}
}
BACKGROUND High-carbohydrate (HC) diets increase de novo lipogenesis (DNL), but effects on stearoyl-CoA desaturase (SCD) are not so well studied. OBJECTIVE The objective was to investigate DNL and SCD in liver and adipose tissue by using fatty acid ratios after short-term dietary intervention. DESIGN Eight subjects consumed isoenergetic 3-d HC (10% fat; 75% carbohydrates) or higher fat (HF; 40% fat; 45% carbohydrates) diets (sugar to starch ratio: 60:40 for both) in a crossover study. Blood… CONTINUE READING
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