Parallel Quorum Sensing Systems Converge to Regulate Virulence in Vibrio cholerae

@article{Miller2002ParallelQS,
  title={Parallel Quorum Sensing Systems Converge to Regulate Virulence in Vibrio cholerae},
  author={Melissa B. Miller and Karen Skorupski and Derrick H. Lenz and Ronald K. Taylor and Bonnie L. Bassler},
  journal={Cell},
  year={2002},
  volume={110},
  pages={303-314}
}
The marine bacterium Vibrio harveyi possesses two quorum sensing systems (System 1 and System 2) that regulate bioluminescence. Although the Vibrio cholerae genome sequence reveals that a V. harveyi-like System 2 exists, it does not predict the existence of a V. harveyi-like System 1 or any obvious quorum sensing-controlled target genes. In this report we identify and characterize the genes encoding an additional V. cholerae autoinducer synthase and its cognate sensor. Analysis of double… Expand

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