Parallel Patterns of Evolution in the Genomes and Transcriptomes of Humans and Chimpanzees

@article{Khaitovich2005ParallelPO,
  title={Parallel Patterns of Evolution in the Genomes and Transcriptomes of Humans and Chimpanzees},
  author={P. Khaitovich and I. Hellmann and W. Enard and Katja Nowick and M. Leinweber and Henriette Franz and G. Weiss and M. Lachmann and S. P{\"a}{\"a}bo},
  journal={Science},
  year={2005},
  volume={309},
  pages={1850 - 1854}
}
The determination of the chimpanzee genome sequence provides a means to study both structural and functional aspects of the evolution of the human genome. Here we compare humans and chimpanzees with respect to differences in expression levels and protein-coding sequences for genes active in brain, heart, liver, kidney, and testis. We find that the patterns of differences in gene expression and gene sequences are markedly similar. In particular, there is a gradation of selective constraints… Expand
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